Laboratory of Molecular Neurogenetics

Our Research

We are interested in how gene expression is regulated in the brain and how this process influence neurodegenerative diseases, psychiatric disorders and brain tumors. Our current focus is to study the role of epigenetic mechanisms and microRNAs. Our technical expertise include lentiviral vectors, transgenic mice and stem cells cultures.

Aims

• To understand the role of the epigenetic co-repressor protein TRIM28 in the control of transposable elements (TEs) and how TEs control gene regulation in the developing and adult brain.
• To understand the functional analyses of miRNAs and their role in neural stem cells by characterizing and identifiying known and novel RNAs bound to the mouse and human RNA induced Silencing Complex in various cell types of the brain.
• To understand how alterations in autophagy contribute to the pathophysiology of chronic neurodegenerative disorders of the CNS, such as Parkinson’s disease (PD) or Huntington’s disease (HD).
• To develop vector-based strategies of CRISPR/Cas9-mediated gene editing in the brain for experimental and therapeutic purposes.

Impact

List of Team Jakobsson's publications

Team

(name linked to profile in Lund University research portal)

Johan Jakobsson 

Principal Investigator, Johan [dot] Jakobsson [at] med [dot] lu [dot] se (Johan[dot]Jakobsson[at]med[dot]lu[dot]se)    

Karolina Pircs 

Associate Senior Lecturer, Karolina [dot] Pircs [at] med [dot] lu [dot] se (Karolina[dot]Pircs[at]med[dot]lu[dot]se) 

Patricia Gerdes

Postdoc, Patricia [dot] Gerdes [at] med [dot] lu [dot] se (Patricia[dot]Gerdes[at]med[dot]lu[dot]se)

Vivien Horvath

Postdoc, vivien [dot] horvath [at] med [dot] lu [dot] se (Vivien[dot]Horvath[at]med[dot]lu[dot]se)

Laura Castilla Vallmanya

Postdoc, Laura [dot] Castilla_Vallmanya [at] med [dot] lu [dot] se (Laura[dot]Castilla_Vallmanya[at]med[dot]lu[dot]se)

Sara Bermudez

Postdoc, sara [dot] bermudez [at] med [dot] lu [dot] se (sara[dot]bermudez[at]med[dot]lu[dot]se)

Raquel Garza 

Postdoc, Raquel [dot] Garza [at] med [dot] lu [dot] se (Raquel[dot]Garza[at]med[dot]lu[dot]se)

Anita Adami

PhD student, Anita [dot] Adami [at] med [dot] lu [dot] se (Anita[dot]Adami[at]med[dot]lu[dot]se)

Ninoslav Pandiloski

PhD student, ninoslav [dot] pandiloski [at] med [dot] lu [dot] se (Ninoslav[dot]Pandiloski[at]med[dot]lu[dot]se)

Ofelia Karlsson

PhD student, ofelia [dot] karlsson [at] med [dot] lu [dot] se (Ofelia[dot]Karlsson[at]med[dot]lu[dot]se)

Ulla Jarl

Biomedical Analyst, Ulla [dot] Jarl [at] med [dot] lu [dot] se (Ulla[dot]Jarl[at]med[dot]lu[dot]se) 

Jenny G Johansson 

Research Engineer, Jenny_G [dot] Johansson [at] med [dot] lu [dot] se (Jenny_G[dot]Johansson[at]med[dot]lu[dot]se)

Yogita Sharma 

Bioinformatician, Yogita [dot] Sharma [at] med [dot] lu [dot] se (Yogita[dot]Sharma[at]med[dot]lu[dot]se) 

Emily Johansson

Assistant researcher, Emily [dot] Johansson [at] med [dot] lu [dot] se (Emily[dot]Johansson[at]med[dot]lu[dot]se)

Chandramouli Muralidharan

PhD Student, Chandramouli [dot] Muralidharan [at] med [dot] lu [dot] se

Carrie Davis-Hansson

PhD Student, carrie [dot] davis-hansson [at] med [dot] lu [dot] se (carrie[dot]davis-hansson[at]med[dot]lu[dot]se)

Lucian Domitrovic

Masters Student

Paulina Pettersson 

Project Administration Paulina [dot] Pettersson [at] med [dot] lu [dot] se (Paulina[dot]Pettersson[at]med[dot]lu[dot]se)