Laboratory of Molecular Neurogenetics
Jakobsson Group
Our Research
We are interested in how gene expression is regulated in the brain and how this process influence neurodegenerative diseases, psychiatric disorders and brain tumors. Our current focus is to study the role of epigenetic mechanisms and microRNAs. Our technical expertise include lentiviral vectors, transgenic mice and stem cells cultures.
Aims
- To understand the role of the epigenetic co-repressor protein TRIM28 in the control of transposable elements (TEs) and how TEs control gene regulation in the developing and adult brain.
- To understand the functional analyses of miRNAs and their role in neural stem cells by characterizing and identifiying known and novel RNAs bound to the mouse and human RNA induced Silencing Complex in various cell types of the brain.
- To understand how alterations in autophagy contribute to the pathophysiology of chronic neurodegenerative disorders of the CNS, such as Parkinson’s disease (PD) or Huntington’s disease (HD).
- To develop vector-based strategies of CRISPR/Cas9-mediated gene editing in the brain for experimental and therapeutic purposes.
Impact
List of Team Jakobsson's publications
Team
(name linked to profile in Lund University research portal)
Johan Jakobsson
Principal Investigator, Johan [dot] Jakobsson [at] med [dot] lu [dot] se (Johan[dot]Jakobsson[at]med[dot]lu[dot]se)
Karolina Pircs
Associate Senior Lecturer, Karolina [dot] Pircs [at] med [dot] lu [dot] se (Karolina[dot]Pircs[at]med[dot]lu[dot]se)
Patricia Gerdes
Postdoc, Patricia [dot] Gerdes [at] med [dot] lu [dot] se (Patricia[dot]Gerdes[at]med[dot]lu[dot]se)
Vivien Horvath
Postdoc, vivien [dot] horvath [at] med [dot] lu [dot] se (Vivien[dot]Horvath[at]med[dot]lu[dot]se)
Laura Castilla Vallmanya
Postdoc, Laura [dot] Castilla_Vallmanya [at] med [dot] lu [dot] se (Laura[dot]Castilla_Vallmanya[at]med[dot]lu[dot]se)
Sara Bermudez
Postdoc, sara [dot] bermudez [at] med [dot] lu [dot] se (sara[dot]bermudez[at]med[dot]lu[dot]se)
Raquel Garza
Postdoc, Raquel [dot] Garza [at] med [dot] lu [dot] se (Raquel[dot]Garza[at]med[dot]lu[dot]se)
Anita Adami
PhD student, Anita [dot] Adami [at] med [dot] lu [dot] se (Anita[dot]Adami[at]med[dot]lu[dot]se)
Ninoslav Pandiloski
PhD student, ninoslav [dot] pandiloski [at] med [dot] lu [dot] se (Ninoslav[dot]Pandiloski[at]med[dot]lu[dot]se)
Ofelia Karlsson
PhD student, ofelia [dot] karlsson [at] med [dot] lu [dot] se (Ofelia[dot]Karlsson[at]med[dot]lu[dot]se)
Ulla Jarl
Biomedical Analyst, Ulla [dot] Jarl [at] med [dot] lu [dot] se (Ulla[dot]Jarl[at]med[dot]lu[dot]se)
Jenny G Johansson
Research Engineer, Jenny_G [dot] Johansson [at] med [dot] lu [dot] se (Jenny_G[dot]Johansson[at]med[dot]lu[dot]se)
Marie Persson Vejgården
Biomedical Analyst, Marie [dot] Persson_Vejgarden [at] med [dot] lu [dot] se (Marie[dot]Persson_Vejgarden[at]med[dot]lu[dot]se)
Yogita Sharma
Bioinformatician, Yogita [dot] Sharma [at] med [dot] lu [dot] se (Yogita[dot]Sharma[at]med[dot]lu[dot]se)
Emily Johansson
Assistant researcher, Emily [dot] Johansson [at] med [dot] lu [dot] se (Emily[dot]Johansson[at]med[dot]lu[dot]se)
Chandramouli Muralidharan
PhD Student, Chandramouli [dot] Muralidharan [at] med [dot] lu [dot] se
Carrie Davis-Hansson
Project assistant, carrie [dot] davis-hansson [at] med [dot] lu [dot] se (carrie[dot]davis-hansson[at]med[dot]lu[dot]se)
Agnese Pinzi
Masters Student, agnese [dot] pinzi [at] med [dot] lu [dot] se (agnese[dot]pinzi[at]med[dot]lu[dot]se)
Marta Czeladzka
Student, marta_maria [dot] czeladzka [dot] 1436 [at] student [dot] lu [dot] se (marta_maria[dot]czeladzka[dot]1436[at]student[dot]lu[dot]se)
Paulina Pettersson
Project Administration Paulina [dot] Pettersson [at] med [dot] lu [dot] se (Paulina[dot]Pettersson[at]med[dot]lu[dot]se)
Johan Jakobsson
Lund Stem Cell Center Director
Principal Investigator
PhD, Professor
Division of Neurobiology
Department of Experimental Medical Science
Lund Stem Cell Center
Wallenberg Neuroscience Center
BMC A11, Lund University
221 84 Lund, Sweden
Phone: + 46 46 222 42 25
Mail:Johan [dot] Jakobsson [at] med [dot] lu [dot] se (Johan[dot]Jakobsson[at]med[dot]lu[dot]se)
Website: www.molecular-neurogenetics.lu.se